The risk factors for developing new or worsened white matter injury were assessed using uni- and multivariate logistic regression.Ī total of 37 neonates with HLHS were studied. Anatomic magnetic resonance imaging was performed before and approximately 1 week after surgery to quantify the extent and timing of the acquired white matter injury. Neonates with HLHS were recruited for pre- and postoperative monitoring of cerebral oxygen saturation, cerebral oxygen extraction fraction, and cerebral blood flow using 2 noninvasive optical-based techniques: diffuse optical spectroscopy and diffuse correlation spectroscopy. Approximately one half of HLHS survivors will exhibit neurobehavioral symptoms believed to be associated with this injury, although the exact timing of the injury is unknown. Hypoxic-ischemic white mater brain injury commonly occurs in neonates with hypoplastic left heart syndrome (HLHS). 9 Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pa.8 Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pa.7 Division of Cardiothoracic Surgery, The Children's Hospital of Philadelphia, Philadelphia, Pa.6 Division of Cardiothoracic Anesthesia, The Children's Hospital of Philadelphia, Philadelphia, Pa.5 Division of Pediatric Cardiology, Loma Linda University Children's Hospital, Loma Linda, Calif.4 Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pa.3 Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pa.
Martinos Center for Biomedical Imaging, Optics Division, Massachusetts General Hospital, Charlestown, Mass Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pa.
Electronic address: 2 Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pa Athinoula A. 1 Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pa.
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